Native mass spectrometry: building a bridge between structural and systems biology

Tuesday 8 Sept 2015, 14:00 → 18:00 Europe/Berlin

Seminar Room 4, building 1b (DESY Hamburg)

In native mass spectrometry (MS) higher order protein structures are preserved. The stoichiometry, topology, conformation and dynamics of protein complexes can be investigated. The method benefits from high sensitivity and broad applicability, even membrane and endogenously expressed protein complexes can be studied.
The symposium aims at illustrating the potential of MS and in particular native MS for structural biology and infection biology as carried out at the CSSB. We have invited four international speakers highlighting different aspects of the technique:
- ion mobility to study the conformation of membrane protein complexes
- new fragmentation techniques to study protein complexes
- analysis of endogenous protein complexes, characterizing enzymatic mechanisms
- virus assembly as well as the required commercial instrumentation.
Participation in the symposium is free of charge. However, in order to be able to plan ahead, we we would ask you to register, if you are planning to attend.
Confirmed Speakers: Albert J.R. Heck, Utrecht University, the Netherlands Michal Sharon, Weizmann Institute, Israel Frank Sobott, University of Antwerp, Belgium Jonathan Williams, Waters
Organisers: Rob Meijers, EMBL Hamburg, Germany Charlotte Uetrecht, Heinrich Pette Institute, Germany
Sponsored by: Centre for Structural Systems Biology (CSSB) European Molecular Biology Laboratory (EMBL) Heinrich Pette Institute (HPI)

Graphic MS_Symposium.jpg

Travel Information Travel_Information.pdf

14:00 → 14:10 Welcome Address

14:10 → 15:00 Structure and assembly of viruses studied by mass spectrometry - Albert Heck (Utrecht University, The Netherlands)

15:00 → 15:50 The emerging role of native mass spectrometry in structure & function analyisis of cellular complexes - Michal Sharon (Weizmann Institute of Science, Israel)

15:50 → 16:20 Coffee Break

16:20 → 17:10 Talk title tbc - Jonathan Williams (Waters Limited, UK)

17:10 → 18:00 Novel MS approaches for the structural characterisation of membrane proteins - Frank Sobott (University of Antwerp, Belgium)