Hamburg Photon Science Colloquium | Dynamic interactions in cancer biology

by Maria Sunnerhagen (Department of Physics, Chemistry and Biology Linköping University, Sweden)

Friday 7 Dec 2018, 14:00 → 15:30 Europe/Berlin

CFEL SR I-III (Bldg. 99) (DESY, Hamburg)

Balancing normal cell growth requires maximal molecular adaptability. A single protein may be required to interact with several hundred different partners, with maintained specificity but with built-in versatility in the response. The oncoprotein c-Myc belongs to the intrinsically disordered (IDP) group of proteins, and is an oncogenic master regulator overexpressed in more than half of human cancers. We use a combination of NMR, SAXS, BioID and crystallography to describe its interactions.