European XFEL Science Seminar

Mechanistic insight into vitamin B12 chemistry: femtosecond x-ray spectroscopy of cobalamins

by Prof. James Penner-Hahn (Departments of Chemistry and Biophysics, University of Michigan)

Zoom meeting

Zoom meeting


Vitamin B12 is a family of biologically essential cofactors containing a cobalt that is coordinated equatorially to a corrin ring and axially to a variety of possible ligands.  The Co site in vitamin B12 catalyzes a wide range of both 1- and 2-electron reactivity.  The B12 unit has a rich, well-characterized photochemistry which is believed to have direct relevance to its non-photochemical reactivity.  This connection has grown stronger with the recent discovery that some organisms use B12 as the photosensor for a photoactivated transcriptional regulation.  This talk will explore the ability of both K- and L-edge X-ray absorption and X-ray emission to elucidate the photophysics and photochemistry of vitamin B12, with particular emphasis on femtosecond time-resolved measurements. 

Join Zoom Meeting

Meeting ID: 971 8840 7576
Passcode: 425530

Organized by

Sakura Pascarelli / Gabriella Mulá-Mathews