European XFEL Science Seminar

Shifting time-resolved structural biology from a niche pursuit to a standard experiment

by Prof. Arwen Pearson (UNI/CUI (The Hamburg Centre for Ultrafast Imaging))




Time-resolved structural biology enables the direct visualisation of
biomolecular processes with high spatial and temporal resolution.
Despite such experiments being technically possible for decades, the
stringent experimental requirements restricted their application beyond
a very few suitable systems. With the advent of high brilliance XFELs
and microfocus 3rd synchrotron beamlines, coupled with serial data
collection approaches, many of these stringent experimental requirements
have been relaxed. This opens the door to time-resolved structural
experiments becoming a routine part of the structural biologists tool
kit. In this talk I will present some of these developments as well as
lessons learned from the first years of operation of T-REXX, a dedicated
endstation for time-resolved serial synchrotron crystallography at the
P14 Beamline at PETRA III.

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Meeting ID: 988 4680 9859
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Organized by

Serguei Molodtsov / Gabriella Mulá-Mathews