Macromolecular Crystallography - quo vadis

by Thomas Schneider (EMBL c/o DESY)


Structural Biology is a technology-driven and very dynamic field. For decades, Macromolecular Crystallography ('MX') has been the undisputed leading technology for obtaining information about the structure of biological macromolecules. During recent years, this position has been challenged, in particular by the 'resolution revolution' in Cryo-EM and the arrival of AlphaFold, an AI-based system for the prediction of protein structures. I will discuss various aspects of this situation including the relevance for future synchrotron beamlines.