PETRA III Science Seminar | The role of collagen fibrils in breast cancer metastasis by SAXS Tensor Tomography at the SAXSMAT beamline

by Andre Luiz Coelho Conceicao (FS-PETRA-D (FS-PET-D Fachgruppe P62 (SmallAngleSc)))

Tuesday 4 Apr 2023, 14:15 → 15:00 Europe/Berlin

FLASH Seminar Room

Breast cancer is the leading cause of cancer death in women worldwide. In these patients, more than 90% of breast cancer-related deaths are caused not by the primary tumor, but by their metastases at distant sites. Systemic changes in the microenvironment between the cancer cells and the host stroma play an important role in supporting the growth and progression of the tumor by degrading, re-depositing, cross-linking and stiffening collagen fibrils. Although the knowledge of breast carcinogenesis is being progressively elucidated with 2D cell-culture experiments, they are not able to reproduce the real physiological pattern of the tumor microenvironment where the surrounding cells are equally as important as the tumor cell itself. In this presentation, it will be shown how the use of the SAXS Tensor Tomography setup at the beamline SAXSMAT P62 can be used to try to reveal the role of the collagen fibrils in the breast cancer metastasis process.