Conveners
Biological Mechanisms of the effect of Particle Minibeams
- John Eley (Vanderbilt University)
A higher therapeutic index might be achieved in carbon therapy when used in combination with Minibeam Radiation Therapy (CMBRT). Nevertheless, the biochemical effects underlying CMBRT are not profoundly known. This work aims to study the nature of these effects by employing synchrotron-based Fourier Transform Infrared microspectroscopy (SR-FTIRM).
Cancer cell irradiations (LM8 mouse...
Background: the biology underlying proton minibeam radiation therapy (pMBRT) is not fully known yet. Therefore, this study reports on the in vivo biochemical mechanisms following pMBRT irradiations using Fourier Transform Infrared Microspectroscopy (FTIRM). This technique can reveal details of the biochemical structure of the main biomolecules and their possible modifications by measuring...
Glioblastoma multiforme is the most common malignant brain tumor with a very poor prognosis. High infiltration rates, uncontrolled cell growth, and a strong ability to develop therapy resistance are components of the aggressive nature of this type of cancer. Despite multimodal treatment, the tumor often recurs within 1-2 cm of the primary tumor.
In this study, the migration behavior of U87...
The existence of severe hypoxia in locally advanced tumors is well characterized. In terms of particle minibeam applications, few studies have considered the dose that may be required to completely sterilize tumor tissue that falls within the peak dose volumes. Instead, peak doses are mostly decided at random and dictated by valley dose treatment goals or anatomic constraints depending on...
Particle minibeam radiation therapy (PMBT) is a novel therapeutic approach offering great promise for
the treatment of radioresistant tumors based on the spatial fractionation of the dose and the combination
with particle therapy. PMBT offers a high dose modulation consisting of high doses (peaks) deposited in
the paths of millimetric planar beams and low doses (valleys) in the rest of the...
