Conveners
Technologies of Particle Minibeam production and application
- Günther Dollinger (Universität der Bundeswehr München)
The radiation biology research at the UMCG PARTREC accelerator facility was pivotal in providing pre-clinical evidence for introduction of proton therapy as a cancer treatment modality in the Netherlands. UMCG PARTREC (formerly known as KVI-CART) operates the unique superconducting cyclotron AGOR that provides customizable ion beams of all stable elements, that are employed for a wide range of...
The main parameters for minibeams that seem to affect the magnitude of the sparing effect are the peak/valley dose ratio, the FWHM and the distance between peaks. The quantitative dependencies of the minibeam effect on these parameters are not yet fully understood. Therefore, a systematic investigation of the variations of the biological effects in vitro and in vivo (small animals) as a...
Purpose:
Microbeam and minibeam radiotherapy are the most extreme forms of spatially fractionated photon radiotherapy. Both techniques may improve cancer treatment substantially because they preclinically demonstrated high dose tolerances of normal tissue at similar tumor control rates as conventional radiotherapy. However, until now, suitable clinical treatment facilities are lacking, which...
Preclinical studies comparing proton minibeams (pMB) with proton broad-beams (pBB) have demonstrated that pMB can improve the sparing of healthy tissues while there are also indications for an increase in therapeutic index. Minibeams can be generated either via collimation, a method easier to apply regarding technical purposes, or via magnetic focusing, which even though it is more...
