Conveners
Treatment planning and simulations
- Juergen Meyer (University of Washington)
Purpose: The clinical translation of proton minibeam radiation therapy (pMBRT) is non-trivial, for which the proper treatment planning technique remains an open question: on one hand, the uniform target dose is desirable for anti-tumor efficacy and the easy acceptance of pMBRT as a standalone treatment modality; on the other hand, high peak-to-valley dose ratio (PVDR) is also desirable in...
A wealth of preclinical evidence is demonstrating superior tumour control and less side effects for SFRT. Particularly, the normal tissue tolerance towards extremely high peak doses is the promoting argument for SFRT. However, recent research is showing that peak dose is not the determining factor for toxicity or tumour control. The many parameters required to define the radiation field are a...
