Conveners
Pre-Clinical studies on Particle Minibeam Therapy
- Yolanda prezado
Spatially fractionated radiation therapy (SFRT) has shown promise in increasing the therapeutic window compared to conventional irradiation techniques. However, which dose parameter best correlates highly modulated dose distributions with cellular and clinical endpoints remains unresolved. The aim of this work was to determine the predictive value of several physical and biological dose...
Abstract: The purpose of this work was to investigate whether minibeam therapy with heavy ions might offer improvements of the therapeutic ratio for the treatment of human brain cancers. To assess neurotoxicity, we irradiated normal juvenile rats using 120 MeV lithium‐7 ions at an absorbed integral dose of 20 Gy. Beams were configured either as a solid parallel circular beam or as an array of...
Charged particles, characterized by superior relative biological effectiveness (RBE) and more targeted depth dose deposition as compared with photons, have the potential to significantly enhance the therapeutic index of minibeam radiation therapy (MBRT). Proton minibeam radiation therapy has emerged as a compelling technique, showcasing remarkable normal tissue sparing for both skin and brain...
