Speaker
Lea von Soosten
(UKE)
Description
Mycobacterium abscessus expresses an ADP-ribosyltransferase (ARR) responsible for the inactivation of rifampicin, a commonly used first-line antibiotic to treat M. tuberculosis. In bioinformatics studies orthologues of this protein have been found across different microbial genera, making this an interesting target. Time-resolved X-ray crystallography will be used to examine the structural changes upon substrate binding and during the catalytic process.
