Hamburg Structural Biology Meeting

Session

Chiquitita, tell me what's wrong - Early career edition

11 Sept 2024, 10:30

MPSD seminar room EG.136 (DESY campus, MPSD (Building 900))

Description

Early career scientists wil present their projects focusing on prolems/issues/challenges. Attending (senior) scientists should give their opinion, ideas, suggestions in the following discussion round.
Presentation 15 min, Discussion 5 min

24. Giving a stiff neck to the ribosome: the interesting case of Elansolid(s)

Martino Morici (UHH)

11/09/2024, 10:30

The family of the beta coronaviruses has caused multiple sever outbreaks like SARS, MERS and recently COVID. Due to their high mutation rates, it is likely that they cause further outbreaks in the future. They share a conserved 3C-like main protease (MPro) which is vital for its replication, making it an interesting drug target. To better understand this crucial enzyme, my project is about...

25. Structural studies of human pre-haptoglobin-2

Jialing Song (DESY)

11/09/2024, 10:48

Here we demonstrate preliminary results on the structural studies of human pre-Haptoglobin-2. We have established protocols to recombinantly produce pre-haptoglobin-2 and biophysically characterised it using various methods. Recombinant pre-haptoglobin-2 and its glycosylation sites have been verified by MS. Furthermore, Small-Angle X-rays Scattering (SAXS) has been employed for acquiring a low...

26. Investigating allosteric mechanisms of SARS-CoV-2 MPro

Stephan Kleine-Doepke (UHH)

11/09/2024, 11:06

The family of the beta coronaviruses has caused multiple sever outbreaks like SARS, MERS and recently COVID. Due to their high mutation rates, it is likely that they cause further outbreaks in the future. They share a conserved 3C-like main protease (MPro) which is vital for its replication, making it an interesting drug target. To better understand this crucial enzyme, my project is about...

27. Time-resolved structural analysis of the rifampicin ADP-ribosyltransferase ARR

Lea von Soosten (UKE)

11/09/2024, 11:24

Mycobacterium abscessus expresses an ADP-ribosyltransferase (ARR) responsible for the inactivation of rifampicin, a commonly used first-line antibiotic to treat M. tuberculosis. In bioinformatics studies orthologues of this protein have been found across different microbial genera, making this an interesting target. Time-resolved X-ray crystallography will be used to examine the structural...

28. Development of an automated pipeline for enhanced FBDD campaigns at beamline P11

Veronica Delsoglio (DESY)

11/09/2024, 11:42

Fragment-Based Drug Discovery (FBDD) has emerged as a pivotal approach in drug development, offering notable success with the approval of six drugs by the USFDA and over 15 candidates advancing through clinical trials. Compared to traditional high-throughput screening (HTS), FBDD is more efficient, utilizing smaller libraries of low-molecular-weight molecules that enhance chemical space...