Hamburg Photon Science Colloquium | Gas-phase structures of biomolecular ions produced by native ESI

by Renato Zenobi (ETH Zurich, Switzerland)

Friday 23 Jan 2026, 14:00 → 15:30 Europe/Berlin

SemR I-III (CFEL, Bldg. 99)

Native electrospray ionization (ESI) can produce gas-phase biomolecular ions and their complexes, but it is unclear whether their structures are indeed near-native. This lecture presents a synergistic approach combining ion mobility-mass spectrometry, gas-phase FRET, and microsolvation-based differential mobility to constrain molecular modeling. Applications include various peptides, revealing that only multi-method analysis yields reliable gas-phase structures.

Coffee, tea and cake will be served at 1:45 pm.