Hamburg Photon Science Colloquium | Dynamic interactions in cancer biology
by Maria Sunnerhagen (Department of Physics, Chemistry and Biology Linköping University, Sweden)
at DESY, Hamburg ( CFEL SR I-III (Bldg. 99) )
Balancing normal cell growth requires maximal molecular adaptability. A single protein may be required to interact with several hundred different partners, with maintained specificity but with built-in versatility in the response. The oncoprotein c-Myc belongs to the intrinsically disordered (IDP) group of proteins, and is an oncogenic master regulator overexpressed in more than half of human cancers. We use a combination of NMR, SAXS, BioID and crystallography to describe its interactions.