We study the higher-spin gauge theory in six-dimensional anti-de Sitter space AdS6 that is based on the exceptional Lie superalgebra F(4). The relevant higher-spin algebra was constructed in arXiv:1409.2185 [hep-th]. We determine the spectrum of the theory and show that it contains the physical fields of the Romans F(4) gauged supergravity. The full spectrum consists of an infinite tower of unitary supermultiplets of F(4) which extend the Romans multiplet to higher spins plus a single short supermultiplet. Motivated by applications to this novel supersymmetric higher-spin theory as well as to other theories, we extend the known one-loop tests of AdS/CFT duality in various directions. The spectral zeta-function is derived for the most general case of fermionic and mixed-symmetry fields, which allows one to test the Type-A and B theories and supersymmetric extensions thereof in any dimension. We also study higher-spin doubletons and partially-massless fields. While most of the tests are successfully passed, the Type-B theory in all even dimensional anti-de Sitter spacetimes presents an interesting puzzle: the free energy as computed from the bulk is not equal to that of the free fermion on the CFT side, though there is some systematics to the discrepancy.