The purpose of radiotherapy (RT) in cancer therapy is to destroy malignant cells while sparing normal tissue. In the last years, it has been shown that irradiations with an ultra-high dose rate (i.e., larger than about 40 Gy/s) further spare healthy tissue and has the same effect on tumour cells with respect to irradiations with conventional dose rates (i.e., of the order of 10 Gy/min). This...
The FLASH effect describes the observation of normal tissue protection by
ultra-high dose rates (UHDR), i.e. dose delivery in a fraction of a second, at
similar tumor-killing efficacy of conventional dose delivery and promises
great benefits for radiotherapy patients. Dedicated studies are now necessary
to define a robust and optimum set of dose application parameters for...
This presentation will give an overview of the accelerator related challenges for medical applications. It will focus on the studies performed at ARES, DESY Hamburg.
FLASHlab@PITZ is a new setup for radiobiological irradiation experiments at the PITZ (Photo Injector Test stand at DESY, Zeuthen) accelerator. The main purpose is to investigate the FLASH effect and optimize irradiation parameters. The standard mode of operation is to irradiate samples with high beam current with a single bunch train (up to 4500 bunches within 1 ms). This results in several...
