Speaker
Dr
Francesca Fabbiani
(Georg-August Universität Göttingen)
Description
The application of high pressure is a powerful method for exploring the polymorphic behaviour of simple molecular compounds.[1-4] Direct compression of either single crystals or powders, and crystal growth from the melt are two methods that have been successfully used to prepare new polymorphs.[1-4] The recent development of the experimental technique for in situ high-pressure crystallisation of single crystals from solution has allowed a wider range of compounds to be studied, including small-molecule pharmaceuticals, and has enabled the preparation of new forms at modest pressured, typically 0.1-1.5 GPa.[5] Exemplified with the study of the antibiotic ciprofloxacin,[6] whose chemical formula comprises 24 non-H atoms, we describe how: a) the technique can be extended for the study of larger, more complex compounds of biological importance; b) high-pressure forms can be recovered to ambient-pressure conditions. The key role played by the use of synchrotron radiation for collecting high-quality high-pressure data on single crystals of light-scattering organic compounds is also discussed.
References
[1] R. Fourme, J. Appl. Cryst., 1, 23 (1968).
[2] E. V. Boldyreva, Acta Crystallogr., Sect. A: Found. Crystallogr., 64, 218 (2008).
[3] S. A. Moggach, S. Parsons and P. A. Wood, Crystallogr. Rev., 14, 143 (2008).
[4] A. Katrusiak, Acta Crystallogr., Sect. A: Found. Crystallogr., 64, 135 (2008).
[5] F. P. A. Fabbiani and C. R. Pulham, Chem. Soc Rev., 35, 932 (2006).
[6] F. P. A. Fabbiani, B. Dittrich, A. J. Florence, T. Gelbrich, M. B. Hursthouse, W. F. Kuhs, N. Shankland and H. Sowa, CrystEngComm, Advance Article, DOI: 10.1039/B822987B (2009).
Primary author
Dr
Francesca Fabbiani
(Georg-August Universität Göttingen)
Co-authors
Prof.
Alastair Florence
(University of Strathclyde)
Dr
Heidrun Sowa
(Georg-August Universität Göttingen)
Dr
Norman Shankland
(University of Strathclyde)
Prof.
Werner Kuhs
(Georg-August Universität Göttingen)
